{ "version": "neuro-incertidumbre-v1", "fecha": "2026-09-08", "naturaleza": "Experimento sintético; no observaciones biológicas.", "prioridadCientifica": "No establecida. Antecedentes de cinética integrada, intervalos y estimación por conjuntos encontrados. Propuesta específica y demostraciones locales sujetas a revisión externa.", "cumpleProtocolo": true, "hashFuenteSHA256": "5f064c76321078c6463d28b3fc1ca7cb2301f282c9a3ad5f9c80b4572cba5cd8", "hashProtocoloSHA256": "ee47737765ea23e3f9a09db5bcbf52b3ad0878603421b75fb2f623a656ad13fb", "algoritmoAleatorio": "xorshift32; uniforme [0,1); semillas y rangos fijados en protocolo", "protocolo": { "version": "neuro-incertidumbre-v1", "fecha": "2026-09-08", "estado": "Fijado antes de ejecutar investigar-neuro.mjs; ensayo sintético, sin datos biológicos.", "semilla": 20260908, "casos": 256, "ruidoAbsolutoMicroM": 0.02, "c0MicroM": 2, "rangoVerdadKm": [ 0.05, 0.8 ], "rangoVerdadVmax": [ 0.001, 0.006 ], "priorKm": [ 0.01, 1 ], "priorVmax": [ 0.0001, 0.01 ], "tiemposMedicionMs": [ 50, 150, 300, 500 ], "tiempoPrediccionMs": 700, "comparadorPuntualIndices": [ 0, 3 ], "umbralToleranciaMicroM": 1e-9, "umbralCobertura": "256/256 parámetros verdaderos y predicciones contenidos; condición de error acotado satisfecha por construcción.", "umbralAnchura": "Ninguna predicción del polígono más ancha que la del rectángulo previo, tolerancia 1e-9 μM.", "sinapsis": { "uMin": 0.25, "uMax": 0.45, "tauMinMs": 600, "tauMaxMs": 1000, "objetivo": 0.2, "puntosPorEje": 21 }, "circuito": { "wMin": 1.5, "wMax": 1.9, "hMin": 0.8, "hMax": 1.3, "tauEMinMs": 18, "tauEMaxMs": 22, "tauIMinMs": 8, "tauIMaxMs": 12, "margen": 0.2 }, "alcance": "Los comparadores son puntos medios/inversión puntual y un intervalo previo sin mediciones; muestran consecuencias de ignorar incertidumbre. No son una comparación contra el estado del arte ni contra datos de un cerebro.", "prioridadCientifica": "No establecida. Antecedentes de cinética integrada, intervalos y estimación por conjuntos encontrados. Propuesta específica y demostraciones locales sujetas a revisión externa." }, "resumen": { "sinapsis": { "deltaMinMs": 693.1471805599454, "finito": true, "motivo": "Solución exacta del estado estacionario.", "nominalMs": 306.3938018048847, "peorLiberacionNominal": 0.14729131525138214, "peorLiberacionCertificada": 0.2, "supuestos": "Parámetros constantes en una caja; estado estacionario o r0≥r*. No certifica todos los transitorios para r0 arbitrario.", "total": 441, "cumpleNominal": 207, "cumpleAcotado": 441, "objetivo": 0.2, "unidadIntervalo": "ms", "unidadLiberacion": "fracción del reservorio total" }, "circuito": { "gMin": 1.3749999999999998, "finito": true, "motivo": "Margen positivo de determinante con traza negativa.", "limiteTraza": 2.5, "peorTraza": -0.03333333333333333, "margenDeterminante": 0.19999999999999996, "gNominal": 0.857142857142857, "total": 16, "establesNominal": 12, "establesAcotado": 16, "cumplenMargenNominal": 8, "cumplenMargenAcotado": 16, "peorMaxRealAcotado": -0.016666666666666666, "unidadAutovalor": "ms⁻¹", "unidadGanancia": "adimensional" }, "limpieza": { "total": 256, "parametrosContenidos": 256, "prediccionesContenidas": 256, "regionesVacias": 0, "prediccionPrior": { "min": 1.4249152813482571e-217, "max": 1.9535162345748058, "vacio": false }, "anchoPrior": 1.9535162345748058, "anchuraPoligono": { "n": 256, "media": 0.07973096135394164, "desviacionMuestral": 0.05186318332309219, "min": 3.6167415928373795e-9, "max": 0.2198402052428305 }, "fraccionAnchuraPrior": { "n": 256, "media": 0.04081407665971895, "desviacionMuestral": 0.026548631849164294, "min": 1.8514008375387698e-9, "max": 0.11253564283312956 }, "anchurasMayoresAlPrior": 0, "estimacionesPuntualesFisicas": 177, "errorPuntualAbsoluto": { "n": 177, "media": 0.03182976054003072, "desviacionMuestral": 0.03333768929283652, "min": 1.4100248230926884e-7, "max": 0.20569929411721846 }, "puntualDentroEpsilon": 83, "denominadorPuntual": 256, "unidadConcentracion": "μM" } }, "rejillaSinapsis": [ { "u": 0.25, "tauMs": 600, "qNominal": 0.18179719108975567, "qAcotado": 0.2242247006885477 }, { "u": 0.25, "tauMs": 620, "qNominal": 0.179708891580329, "qAcotado": 0.22292810535839044 }, { "u": 0.25, "tauMs": 640, "qNominal": 0.1776653808125218, "qAcotado": 0.22163799378407933 }, { "u": 0.25, "tauMs": 660, "qNominal": 0.17566546960051932, "qAcotado": 0.22035510009705012 }, { "u": 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"verdadero": 3.1147132584147303e-7, "puntual": { "km": 0.02982022398088297, "vmax": 0.003919850582545145, "fisico": true, "singular": false, "prediccion": 2.931692312041105e-11, "errorAbsoluto": 3.114420089183526e-7 }, "contieneParametros": true, "contienePrediccion": true } ], "limitaciones": [ "C0 conocida exactamente.", "Ruido realmente acotado; los valores atípicos fuera de la cota invalidan la garantía.", "Modelo saturable de un compartimento, sin difusión ni liberación adicional.", "Parámetros de cada caja independientes y constantes.", "Proposiciones en aritmética real; implementación Float64 sin redondeo dirigido.", "Sin comparación contra estimadores publicados del estado del arte.", "Prioridad científica no establecida; no constituye solución de la mente ni una aplicación clínica." ] }